Corpus Callosum Anatomy Mri

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The formation of the corpus callosum begins with the first midline crossing of pioneer axons around week 12 of the human prenatal development, or embryonic day 15 of the mouse. Agenesis of the corpus callosum (ACC) is a rare congenital disorder that is one of the most common brain malformations observed in human beings, in which the corpus callosum is partially or completely absent. ACC is usually diagnosed within the first two years of life, and may manifest as a severe syndrome in infancy or childhood, as a milder condition in young adults, or as an asymptomatic incidental finding. Initial symptoms of ACC usually include seizures, which may be followed by feeding problems and delays in holding the head erect, sitting, standing, and walking. Other possible symptoms may include impairments in mental and physical development, hand-eye coordination, and visual and auditory memory. Hydrocephaly may also occur. In mild cases, symptoms such as seizures, repetitive speech, or headaches may not appear for years. Some syndromes that are often associated with ACC are Aicardi syndrome, Andermann syndrome, Shapiro syndrome, and acrocallosal syndrome.